Yes.  If you are searching for a job in your existing profession, some of the expenses associated with attempting to find a new job may be tax deductible.  You do not have to get the job to write-off these deductions, but there are some stipulations that you should be aware of.

First, the job you are seeking must be in your existing occupation.  This can be a bit confusing because the wording of what defines "occupation" is ambiguous.  For example, if you are a certified flight instructor and you seek a job as a regional airline pilot, is that considered the same occupation?  We contacted the IRS and asked this specific question, and the answer they gave was, "Yes."  Both flight instructors and regional airline pilots are "commercial pilots".  

Second, job searching expenses are considered employee expenses and should be included on line 4, column A, of Form 2106 where it asks for "Business expenses not included on lines 1 through 3. Do not include meals and entertainment."  Because this is entered on IRS Form 2106 along with other work-related expenses, you are subject to the some restrictions.

You must itemize to benefit.
Your expenses are subject to the 2% limit.